Irf3 polymorphism alters induction of IFNβ in response to L. monocytogenes infection
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چکیده
منابع مشابه
Irf3 Polymorphism Alters Induction of Interferon Beta in Response to Listeria monocytogenes Infection
Genetic makeup of the host plays a significant role in the course and outcome of infection. Inbred strains of mice display a wide range of sensitivities to Listeria monocytogenes infection and thus serve as a good model for analysis of the effect of genetic polymorphism. The outcome of L. monocytogenes infection in mice is influenced by the ability of this bacterium to induce expression of inte...
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Dendritic cells (DCs) and natural killer (NK) cells are essential components of the innate immunity and play a crucial role in the first phase of host defense against infections and tumors. Listeria monocytogenes (Lm) is an intracellular pathogen that colonizes the cytosol of eukaryotic cells. Recent findings have shown Lm specifically in splenic CD8a(+) DCs shortly after intravenous infection....
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microRNAs represent a family of very small non-coding RNAs that control several physiologic and pathologic processes, including host immune response and cancer by antagonizing a number of target mRNAs. There is limited knowledge about cell expression and the regulatory role of microRNAs following bacterial infections. We investigated whether infection with a Gram-positive bacterium leads to alt...
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ژورنال
عنوان ژورنال: PLoS Genetics
سال: 2005
ISSN: 1553-7390,1553-7404
DOI: 10.1371/journal.pgen.0030152.eor